PCORI is creating synergies among the data, technology, and methods that researchers, patients, and other stakeholders need to transform health research. There is a critical need to conduct research at a large scale, faster and more efficiently, and to accelerate the participation of populations historically underserved or underrepresented in health research. PCORI has invested in PCORnet®, a national research network, to meet these needs by generating real-world evidence through health data collected in everyday care encounters and settings. These data represent 30 million patients receiving care at more than 40 health systems, each with dozens of practice sites, reflecting the full diversity of the U.S. population. Session speakers will highlight the growth and contributions of PCORnet over the last decade and discuss how PCORnet is poised to continue to support national scale research to speed evidence generation.