Comparing dissemination, implementation, and health communication (DIHC) strategies for increasing the uptake and sustainment of evidence-based practices, or de-implementation of harmful or outdated practices, is integral in identifying the best ways to get evidence into the hands of patients, caregivers, providers, and relevant stakeholders to enable them to make the most informed decisions about healthcare. But once the best strategies are identified through comparative clinical effectiveness research (CER), how are they scaled up and out broadly to make the greatest impact and improve outcomes? This session will review the aims of CER in DIHC and spotlight researchers who have received dissemination and implementation awards to promote awareness of their findings from PCORI-funded research and to facilitate the uptake of these findings into practice settings. A panel of researchers and patient partners will present an overview of their DIHC CER study, results, and impact, then discuss best practices for facilitating uptake of results widely and broadly, beyond the health systems or centers that participated in the CER study. The session will close with a robust Q&A session.